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What is Microdosing?

Five years ago, Joseph began using psychedelic microdosages in an effort to enhance his mental well-being. He explained, “I was just kind of in this depression, in this rut.” “I was constantly agitated, angry, and unhappy, and it wasn’t how I saw myself.”
Joseph’s family has a history of depression and anxiety, and when he was younger, he was taken Prozac. When his depressive symptoms reappeared in his early thirties, however, he refused to take prescription medication again.

A designer living in Austin, Texas, named Joseph (who requested to remain anonymous due to privacy concerns over illicit drug use and mental health concerns) came into a Johns Hopkins University study on psilocybin, the active component of hallucinogenic, or “magic,” mushrooms. Full doses of the medication helped cancer patients manage their anxiety and despair in a limited study. Then he read stories of influential people in Silicon Valley who claimed to have more energy after ingesting small amounts of psychedelics. In order to see if it might lift his spirits, he made the decision to begin microdosing a few times a week by consuming a “small nibble” of mushrooms, or roughly half an inch.

He noticed an advantage almost right away. He stated, “It just kind of boosted my morale.” My mood had slightly improved. My step had a little extra vigor. I was feeling a little bit more thrilled about things and enjoying myself a little bit more.

Experts often characterize microdosing as taking 5–10% of a full dosage of a psychedelic (mainly psilocybin or LSD) in order to obtain the drug’s purported benefits for mental health without experiencing the hallucinogenic high. A 155-pound male, for example, may take 20 milligrams of psilocybin in a clinical environment to achieve a full psychedelic experience. He would just take one or two milligrams as a microdose. When taken at that dosage, multiple times per week, some people report feeling happier, more creative, and as though they are living in a high-definition world.

According to Erin Royal, 30, a bartender in Seattle, who takes mushrooms she forages from surrounding forests once or twice a week as a form of microdosage, it’s like walking outside and the sun suddenly disappears. It serves as a reminder that you are a sentient being with the ability to experience joy and appreciate beauty.

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In reality, only roughly one-third of microdosers take exact measurements of the psychedelic they are ingesting; the majority merely take enough to start experiencing effects, which typically happen an hour later and last for four to six hours. This calls for some trial and error, especially when consuming mushrooms because their psilocybin content varies. Inadvertently taking too much is the most frequently reported adverse side effect of microdosing; this is not harmful, but it can be annoying if you’re at work. Additionally, researchers note that taking psychedelics frequently enough to stress the heart is a theoretical possibility.)

Promising research has been conducted on the potential benefits of full dosages of psychedelics for mental health. An early-phase study even suggested that large doses of psilocybin could be just as useful for treating depression as selective serotonin-reuptake inhibitors. The brain can form new cellular connections through a process known as neuroplasticity when full dosages of psychedelics are taken, and there is some indication that microdoses can also have a similar effect.
A large number of experts who initiated research on full dosages of psychedelics are now investigating the potential benefits of microdosing. However, there is little data, and experts disagree on whether or not microdosing improves people’s health.

Anecdotal evidence from users who reported improved attention and cognition, feelings of wellbeing, and relief from anxiety and depression made up the majority of the early study on microdosing. These assertions are generally supported by laboratory research demonstrating benefits in mood, attentiveness, and creativity with psilocybin and LSD microdoses. However, the majority of these trials were modest in scope and did not contrast a microdose with a placebo.
Dr. David Erritzoe, clinical director of the Centre for Psychedelic Research at Imperial College London, stated, “You probably only participate at this point in a trial in microdosing if you really have a strong belief that this might help you.” Additionally, most people who anticipate benefiting from a medicine actually do so.

Released last year, the results of the two largest microdosing placebo-controlled trials suggest that the benefits patients report are due to the placebo effect. The study participants used their own prescription drugs, and they had no idea that the capsules they were given contained either a placebo or active medication. Whatever they had taken, almost everyone’s mood and overall health had improved by the end of several weeks.
“We were quite optimistic that microdosing could have an effect when we set up the study, so I was initially surprised but also a bit disappointed by the results,” said Michiel van Elk, an assistant professor of cognitive psychology at Leiden University in the Netherlands and the trial’s supervisor, ” beyond a placebo.

The other study’s director, Dr. Erritzoe, discovered a relationship between users’ expectations and the drug’s effectiveness. They felt better if they took a placebo but mistook it for a microdose, and they did not feel better if they took an active dosage but mistook it for a placebo.
In an attempt to circumvent participant expectations, a third placebo-controlled experiment from the University of Chicago was published earlier this month. Participants received four LSD microdoses over the course of two weeks, but they were not informed about the study’s goal or even the medication they were taking. The groups that received LSD and those that received a placebo did not vary from one another.

Nonetheless, other researchers support the validity of microdosing by citing data demonstrating a direct effect on the brain. Researchers have demonstrated similarities between the alterations in brain activity and connectivity observed with higher dosages of LSD through the use of neuroimaging equipment. Furthermore, a Danish study discovered that almost half of the particular subtype of serotonin receptors that psychedelics work on to cause their hallucinatory effects were activated by a microdose of psilocybin.

“I don’t think it’s just a placebo,” It’s obvious that the medication is active, according to University of Chicago psychiatry and behavioral neuroscience professor Harriet de Wit, who oversaw multiple research projects. It appears that the smaller dosages are affecting the same systems because “we see brain changes that are kind of like the high dose effect.”

However, Dr. Erritzoe countered that a drug’s ability to affect the brain does not imply that it has any therapeutic effect. “It’s just not that interesting if you can’t see in a proper trial that it works for the symptoms, for things that people can actually detect, feel, and experience in their lives,” the man stated.

He went on, “I’m not trying to shoot down microdosing.” “I’m just being cautious and saying that things don’t seem very hopeful right now.”
The inability to completely eliminate the placebo effect in investigations involving psychoactive substances is one of the main issues with microdosing research. It’s no longer blindfolded because in Dr. Erritzoe’s trial, 72% of participants correctly predicted what they had taken. The largest alterations were observed in the brains of subjects exposed to the higher end of the microdosing range (20–26 micrograms of LSD and 3 milligrams of psilocybin), which is also the dose at which most subjects begin to experience the effects of the drug.

Most users aim for a similar slight awareness that they have taken something when they dose themselves outside of the lab. At that point, the microdose may be more akin to a half-dose, or since they can sense the drug working, their expectations may be raised to maximize its advantages.
Due to these challenges and the absence of definitive results, Dr. van Elk has returned to researching medication dosages in larger quantities instead of focusing on microdosing. After his next study is over, Dr. Erritzoe said he’ll probably follow suit.

Ms. Royal and Joseph are both aware that the advantages of microdosing might be a hoax. However, the fact that it has aided them is more important to them than how it operates. Joseph claimed that daily meditation has helped his depression these days, though he still takes microdoses on occasion when he starts to feel low.
He claimed that after taking microdosing for a number of years, the largest difference he had noticed was a general shift in his mindset, which is more difficult for scientists to quantify. He explained, “I started because I read that it helps with depression.” “But as time has gone on, it’s really helped a lot more with outlook on life — how you want to live and your existence in the world— and mental and personal growth.”

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